HOME-BASED PULMONARY REHABILITATION: A NARRATIVE REVIEW

Pulmonary rehabilitation is a multidisciplinary, evidence based therapy wherein individually tailored therapies made to improve the physiological and psychological status of chronic respiratory disease patients. We searched 3 databases and term used “home-based pulmonary rehabilitation”. We identified 68 literatures and 8 of them met our inclusion criteria. Our review suggests that home-based pulmonary rehabilitation is effective in chronic respiratory disease patients, further research needed to standardise its quality and benefits.

In vitro anti-inflammatory, anti-arthritic and anti- proliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates)

Abstract Traditionally dates is consumed as a rich source of iron supplement and the current research discuss the synthesis of silver nanoparticles (AgNPs) using methanolic seed extract of Rothan date and its application over in vitro anti-arthritic, anti-inflammatory and antiproliferative activity against lung cancer cell line (A549). FTIR result of synthesised AgNPs reveals the presence of functional group OH as capping agent. XRD pattern confirms the crystalline nature of the AgNPs with peaks at 38º, 44º, 64º and 81º, indexed by (111), (200), (220) and (222) in the 2θ range of 10-90, indicating the face centered cubic (fcc) structure of metallic Ag. HR- TEM results confirm the morphology of AgNPs as almost spherical with high surface areas and average size of 42 ± 9nm. EDX spectra confirmed that Ag is only the major element present and the Dynamic light scattering (DLS) assisted that the Z-average size was 203nm and 1.0 of PdI value. Zeta potential showed − 26.5mv with a single peak. The results of the biological activities of AgNPs exhibited dose dependent activity with 68.44% for arthritic, antiinflammatory with 63.32% inhibition and anti-proliferative activity illustrated IC50 value of 59.66 µg/mL expressing the potential of AgNPs to combat cancer

Trends in the profile of non hodgkins lymphoma in North and South India: a study from two tertiary care hospitals in India

Background: A number of environmental and chemical factors have been thought to been implicated in the occurrence of Non-Hodgkin’s Lymphomas (NHLs).To fill the knowledge gap in various aspect of the disease, this study was undertaken at this tertiary care centre in Delhi and Bangalore.Methods: This was a prospective observational study conducted in two defenses medical centre in India among patients of Non Hodgkins Lymphoma, registered at Command hospital Airforce Bangalore and Army Hospital (Research and Referral), New Delhi, between March 2016 and March 2019.Results: The disease showed a bimodal onset in both centres with 26 (26%) and 24 (24%) cases occurring in the age group of 31-40 years and 24 (24%) and 25 (25%) cases occurring in the age group of >60 years at CHAF (B) and AH (RR) respectively. B cell Lymphoma was the most common type of NHL seen in 85% and 89% patients, whereas T-cell lymphomas constituted 13% and 11% at CHAF (B) and AH (RR).  32(32%) patients presented with an Ann Arbor Stage 1 or 2 disease whereas 68(68%) patients were with Stage 3 or 4 disease at both the centers. IPI score was ≥3 in 45 % and 43% patients.Conclusions: NHL in India is a homogeneous and uniform disease. But there was increased detection of hepatosplenomegaly and associated hepatitis B/C in the southern part of India. Also, the occurrence of Cutaneous T cell lymphoma was only seen in the south India centre. The early stage NHLs has better survival and increase chance of complete response.

Future prospects of fermentation in unani based drugs

Unani system of medicine is being practiced in India for hundreds of years for treating various ailments by its holistic approach with natural means and drugs. Unani formulations are based on herbal, mineral and animal origin. Till date, there is no major development in different forms of the drugs and are being used as they are mentioned in the classical literature. There is need of the hour to devise pharmaceutical processing techniques to achieve palatability, more stability, absorption and assimilability of both single and compound Unani drugs without deviating from the original essence as described in the literature. Fermentation (Takhmīr) may be explored as a unique tool for the modification of dosage forms for herbal Unani drugs. It is a process of chemical change caused by organisms or their products for transformation to another compound of medicinal value. It extracts a wide range of active ingredients from the herb than any other methods of extraction. During fermentation, undesirable molecules like sugars are removed from plant extracts and made the product more bio-available and stable, less toxic and more efficient. In the Unani system of medicine, various products have been mentioned in classical literature where the process of the fermentation is applied for the preparation of drugs like Sirka, Nabeez, Dar Bahra, etc. Fermentation based drugs used in Ayurveda are Asvas and Arishthas are generally found superior to extracts for absorption in the gut with enhanced therapeutic properties, quicker action, and longer shelf life. In order to achieve better therapeutics in Unani Drugs, the process of development of compound formulation based on fermentation should be adopted for different forms of Unani formulations.

A Study of Renal Calyces by Using Barium Contrast.

Objectives: To know the pelvicalyceal anatomy by radiological method that helps in localizing the calculi or tumors in kidneys. Materials and method: The study was conducted in Sri Devaraj Urs Medical College, Tamaka, Kolar from 2011 to 2013. Forty four adult, formalin embalmed cadaveric kidneys (20 right and 24 left) were injected with 8 to 10 ml of 10% radio opaque barium sulphate solution into the renal pelvis and calyces and radiographs were taken in anteroposterior view. Results: The observations were statistically analyzed. There were 14 extra renal pelves and 30 intra renal pelves. The major calyces were classified into three categories [Double (D), Three (T) and Multiple (M) divisions]. Out of 44 kidneys 20 were right and 24 left.. 23 kidneys presented multiple (more than 4) calyces, 12 had two major calyces and only 9 presented with three major calyces). Typical ‘Y’ arrangement in 03 out of 12 and typical multiple in 03 out of 23 kidneys. There were 14 kidneys (31.8%) presented with extra renal pelvis whereas 30 kidneys (68.2%) presented intrarenal formation of the renal pelvis. Conclusion: Due to the variation in the number of major and minor calyces, position of renal pelvis (intrarenal and extra renal), the knowledge of pelvicalyceal anatomy will help the urologist and nephrologists to pin point the position of renal calyceal calculi or malignant growth for the surgery to be carried out.

A recent review on phytochemical constituents and medicinal properties of kesum (Polygonum minus Huds.)

Medicinal plants and herbal preparations are gaining renowned interest in scientific communities nowadays due to their reliable pharmacological actions and affordability to common people which makes them effective in control of various diseases. Polygonum minus (Polygonaceae) locally known as kesum is an aromatic plant commonly used in Malay delicacies. The plant is having potential applications due to its high volatile oil constituents in perfumes and powerful antioxidant activity. It has been used traditionally to treat various ailments including dandruff. The research has been carried out by various researchers using different in vitro and in vivo models for biological evaluations to support these claims. This review paper may help upcoming research activities on Polygonum minus by giving up to date information on the phytochemical constituents and medicinal properties of kesum to a possible extent with relevant data.

Evaluation of anti-bacterial and anti-oxidant potential of andrographolide and echiodinin isolated from callus culture of Andrographis paniculata Nees

Objective: To evaluate the anti-bacterial and anti-oxidant activity of andrographolide (AND) and echiodinin (ECH) of Andrographis paniculata. Methods:In this study, an attempt has been made to demonstrate the anti-microbial and anti-oxidant activity of isolated AND and ECH by broth micro-dilution method and 2,2-diphenyl-2-picryl-hydrazyl (DPPH) assay, respectively. Structure elucidation was determined by electro-spray ionization-MSD, NMR (1H and 13C) and IR spectra. Results: AND was effective against most of the strains tested including Mycobacteriumsmegmatis, showing broad spectrum of growth inhibition activity with Minimum inhibitory concentration values against Staphylococcus aureus (100 μg/mL), Streptococcus thermophilus (350 μg/mL) Bacillus subtilis (100 μg/mL), Escherichia coli (50 μg/mL), Mycobacterium smegmatis (200 μg/mL), Klebsiella pneumonia (100 μg/mL), and Pseudomonas aeruginosa (200 μg/mL). ECH showed specific anti-bacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa at a concentration higher than 225 μg/mL. Both AND and ECH were not effective against the two yeast strains, Candida albicans and Saccharomyces cerevisiae tested in this study. Conclusion:This preliminary study showed promising anti-bacterial activity and moderate free radical scavenging activity of AND and ECH, and it may provide the scientific rationale for its popular folklore medicines.

Ethnomedicinal Observations from the Anantprasad and Jeypur Tribal Villages of district Cuttack, Odisha, India.

Ethnobotanical survey tours were conducted during year 2010-2011 to document the ethnomedicinal remedies for various ailments of the Kondh tribe inhabiting in the Anantprasad and Jeypur villages of district Cuttack, Odisha, India under Athagarh Forest Division. The paper presents 24 plants species belonging to 23 genera and 16 families used by Kondh tribes of this area and other local inhabitants etc. for the treatment of various diseases i. e. boils, cuts & wounds, joints pain, jaundice, constipation, earache, headache, dysentery, menstrual problems, snake-bite etc. The Plants are arranged alphabetically with their botanical name, family in bracket, local name, unani name wherever available, locality with collection number, part used, name of the disease(s) against which used, mode of preparation and administration and Informant who shared his valuable information is given for each recipe discussed. The information provided will help to discover new herbal drugs for many of the diseases, thus far, incurable in modern medicine.

Modification of medical outcome study (MOS) instrument for quality of life assessment & its validation in HIV infected individuals in India.

BACKGROUND & OBJECTIVE: Several instruments have been developed specifically to assess the quality of life (QOL) in HIV infected individuals. No information is available in this aspect from India. The present study was thus carried out to assess the QOL among HIV infected persons, to study their relationship with socio-demographic characteristics and stages of disease progression, and to examine change in QOL over time. METHODS: One time assessment of QOL on 100 and repeat evaluation on 20 HIV infected persons enrolled in an ongoing longitudinal prospective study of clinical progression was done. Medical Outcome Study (MOS-QOL) core instrument was modified to suit the Indian cultural settings and interview-administered. RESULTS: The overall scale had Cronbach alpha 0.75. Instrument showed significant positive inter-domain correlations and linear association between QOL scores and CD4 counts. QOL was markedly affected in the domains of physical health, work and earnings, routine activities, and appetite and food intake. Women had significantly lower QOL scores despite having less advanced disease. The QOL scores decreased with drop in CD4 counts mainly in the physical health domains. Generally, the QOL scores were high in the follow up visit compared to baseline. INTERPRETATION & CONCLUSION: The modified MOS scale with Cronbach alpha of more than 0.7 and linear relationship between CD4 counts and the QOL scores indicated that the instrument was reliable and valid for evaluation of QOL in HIV infected persons in India. Comparative lower scores in the domains of physical health indicate medical intervention to greatly benefit the HIV infected persons. Longitudinal studies need to be undertaken to assess the impact of introduction of anti retroviral therapy (ART) through the national programme on disease progression and changes in QOL.